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[鼠伤寒沙门氏菌——检测环境污染物致突变活性的测试系统。II. 重金属盐在具有代谢活化作用的体外系统中的致突变效应]

[Salmonella typhimurium--test system for detecting the mutagenic activity of environmental pollutants. II. Mutagenic effect of heavy metal salts in an in vitro system with metabolic activation].

作者信息

Polukhina G N, Kalinina L M, Lukasheva L I

出版信息

Genetika. 1977;13(8):1492-4.

PMID:334635
Abstract

Mutagenic effect of zinc chloride on Salmonella typhimurium strain was detected using in vitro metabolic activation system. Cadmium chloride showed no significant mutagenic activity in the same system. It is recommended to use both in vitro and in vivo metabolic activation systems in mutagenicity testing of chemicals.

摘要

使用体外代谢活化系统检测了氯化锌对鼠伤寒沙门氏菌菌株的致突变作用。在同一系统中,氯化镉未显示出明显的致突变活性。建议在化学品的致突变性测试中同时使用体外和体内代谢活化系统。

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