[苯并(a)芘及其代谢产物在鼠伤寒沙门氏菌-微粒体体外试验系统中的致突变作用]
[Mutagenic action of benz(a)pyrene and its metabolites in the in vitro Salmonella typhimurium-microsomes test system].
作者信息
Tolcheev Iu D, Khitrovo I A, Kobliakov V A
出版信息
Biull Eksp Biol Med. 1980 Aug;90(8):208-10.
PMID:6996763
Abstract
It has been shown that epoxides are responsible for the mutagenic action of benz(a)pyrene in the system. S. typhimurium. The mutagenic effect produced by 6-hydroxybenz(a)pyrene that is consequent on the free radical processes is reversed by alpha-tocopherol. Diolepoxides with spatially separated functional groups do not elicit any mutagenic effect.
摘要
业已表明，环氧化物在鼠伤寒沙门氏菌系统中是苯并(a)芘致突变作用的原因。由自由基过程导致的6-羟基苯并(a)芘产生的致突变效应可被α-生育酚逆转。具有空间分离官能团的双环氧化物不会引发任何致突变效应。
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