D'Amato Anthony R, Ding Xiaochu, Wang Yadong
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 134 Hollister Drive, 283 Kimball Hall, Ithaca, New York 14853-0001, United States.
ACS Biomater Sci Eng. 2021 Feb 8;7(2):400-407. doi: 10.1021/acsbiomaterials.0c01419. Epub 2021 Jan 18.
Multiple additive manufacturing techniques have been developed in recent years to produce structures with tunable physical, chemical, and mechanical properties and defined architecture. Solution electrospinning, although an older and more established technique, normally cannot achieve the pattern resolution and tunability of these newer manufacturing techniques. In this study, we present solution electrowriting as a method to produce fibrous conduits from various polymers with tunable patterns, dimensions, and scaffold porosity. We demonstrate the importance of solvent selection during solution electrowriting and discuss how solvent polarity and volatility can be exploited to controllably alter the structure of the resulting scaffolds. The technique can be readily implemented with equipment for conventional electrospinning and offers versatility, control, and customization that is uncommon in the solution electrospinning field.
近年来，人们开发了多种增材制造技术，以生产具有可调节物理、化学和机械性能以及特定结构的结构。溶液静电纺丝虽然是一种较古老且更成熟的技术，但通常无法达到这些较新制造技术的图案分辨率和可调性。在本研究中，我们提出溶液电写作为一种从各种聚合物生产具有可调图案、尺寸和支架孔隙率的纤维导管的方法。我们展示了溶液电写过程中溶剂选择的重要性，并讨论了如何利用溶剂极性和挥发性来可控地改变所得支架的结构。该技术可以很容易地用传统静电纺丝设备实现，并提供了溶液静电纺丝领域中罕见的通用性、可控性和定制性。
