Department of Psychological Sciences, University of Missouri.
Personal Disord. 2022 Jan;13(1):75-83. doi: 10.1037/per0000480. Epub 2021 Jan 18.
Co-use of alcohol and medication can have serious negative health effects (e.g., overdose risk, liver damage). Research has primarily focused on older adults or the pharmacokinetics of specific medication-alcohol combinations. Little work has focused on the subjective experience of persons who take alcohol-interactive (AI) medications and also drink alcohol, particularly in psychiatric samples at high risk for problematic alcohol use and high rates of prescription medication use, such as individuals with borderline personality disorder (BPD). Data from a larger ecological momentary assessment study of alcohol use in 52 persons diagnosed with BPD (83% women; Mage = 26 years) were used to examine the influence of alcohol intoxication (i.e., estimated blood alcohol concentration [eBAC]) and medication co-use on momentary subjective experience while drinking. Participants reported AI medication use at baseline and completed multiple ecological momentary assessment reports per day over 21 days, which included reports of alcohol use, subjective effects of alcohol (e.g., pleasure, feeling worse), and negative and positive affect. AI medications significantly moderated the association between eBAC and pleasurable effects of alcohol, such that at higher levels of eBAC, those taking AI medications experienced blunted subjective pleasure compared with those not taking AI medications. AI medications did not moderate the associations between eBAC and subjective relief, feeling worse, positive affect, or negative affect. Attenuated pleasure during drinking could lead to increased drinking in an attempt to achieve a desirable state among individuals who co-use psychiatric medications and alcohol, and therefore may represent a useful target for prevention and intervention. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
酒精和药物的共同使用会对健康产生严重的负面影响（例如，过量风险、肝损伤）。研究主要集中在老年人或特定药物-酒精组合的药代动力学上。很少有工作关注同时服用酒精相互作用（AI）药物和饮酒的人的主观体验，特别是在有边缘型人格障碍（BPD）等有问题饮酒和高处方药物使用风险的精神科样本中。来自对 52 名 BPD 患者（83%为女性；Mage=26 岁）饮酒进行的更大的生态瞬时评估研究的数据被用于检查酒精中毒（即估计血液酒精浓度[eBAC]）和药物共同使用对饮酒时即时主观体验的影响。参与者在基线时报告 AI 药物使用情况，并在 21 天内每天完成多次生态瞬时评估报告，其中包括饮酒报告、酒精的主观影响（例如愉悦感、感觉更糟）以及负面和正面影响。AI 药物显著调节了 eBAC 和酒精愉悦效果之间的关联，以至于在更高的 eBAC 水平下，服用 AI 药物的人比未服用 AI 药物的人体验到的主观愉悦感减弱。AI 药物并没有调节 eBAC 与主观缓解、感觉更糟、积极影响或消极影响之间的关联。在饮酒过程中愉悦感减弱可能会导致更多的饮酒，以试图在同时使用精神科药物和酒精的个体中达到理想状态，因此可能是预防和干预的一个有用目标。（PsycInfo 数据库记录（c）2022 APA，保留所有权利）。
