Experimental Neurophysiology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy/University Vita-Salute San Raffaele, Milan, Italy.
Clinical Neuroimmunology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Hospital, Milan, Italy.
Mult Scler. 2021 Sep;27(10):1606-1610. doi: 10.1177/1352458520987542. Epub 2021 Jan 19.
Extracellular vesicles (EVs), a recently described mechanism of cell communication, are released from activated microglial cells and macrophages and are a candidate biomarker in diseases characterized by chronic inflammatory process such as multiple sclerosis (MS).
We explored cerebrospinal fluid extracellular vesicle (CSF EV) of myeloid origin (MEVs), cytokine and chemokine levels in patients with clinically isolated syndrome (CIS).
We found that CSF MEVs were significantly higher in CIS patients than in controls and were inversely correlated to CSF CCL2 levels. MEVs level were significantly associated with an shorter time to evidence of disease activity (hazard ratio: 1.01, 95% confidence interval: 1.00-1.02, < 0.01) independently from other known prognostic markers.
After a first demyelinating event, CSF EVs may improve risk stratification of these patients and allow more targeted intervention strategies.
细胞外囊泡 (EVs) 是一种最近被描述的细胞通讯机制，由激活的小胶质细胞和巨噬细胞释放，是多发性硬化症 (MS) 等慢性炎症过程特征疾病的候选生物标志物。
我们研究了临床孤立综合征 (CIS) 患者的脑脊液细胞外囊泡 (CSF EV) 的髓系来源 (MEVs)、细胞因子和趋化因子水平。
我们发现 CIS 患者的 CSF MEVs 明显高于对照组，并且与 CSF CCL2 水平呈负相关。MEVs 水平与疾病活动证据出现的时间更短显著相关（风险比：1.01，95%置信区间：1.00-1.02， <0.01），与其他已知的预后标志物无关。
在首次脱髓鞘事件后，CSF EVs 可能改善这些患者的风险分层，并允许更有针对性的干预策略。
