Department of Dermatology, University of Pennsylvania, Philadelphia, USA.
Cutis. 2020 Nov;106(5):E11-E14. doi: 10.12788/cutis.0122.
Nail unit squamous cell carcinoma (NSCC) is a malignant neoplasm that can arise from any part of the nail unit including the nail bed, nail matrix, nail groove, and nail fold. Nail unit SCC is the most common malignant nail neoplasm, and yet its diagnosis often is delayed, partly due to the clinical presentation of NSCC mimicking benign conditions such as onychomycosis, warts, and paronychia. Nail unit SCC has a low rate of metastasis; however, a delayed diagnosis often can result in local destruction and bone invasion. It is imperative for dermatologists who are early in their training to recognize this entity and refer for treatment. Many approaches have been used to treat NSCC, including wide local excision, digital amputation, cryotherapy, topical modalities, and recently Mohs micrographic surgery (MMS).
甲单元鳞状细胞癌（NSCC）是一种恶性肿瘤，可发生于甲单元的任何部位，包括甲床、甲母质、甲槽和甲皱襞。甲单元 SCC 是最常见的恶性甲肿瘤，但由于其临床表现类似于良性疾病，如甲真菌病、疣和甲沟炎，因此常被延误诊断。甲单元 SCC 的转移率较低；然而，诊断延迟通常会导致局部破坏和骨侵犯。对于刚接触这一领域的皮肤科医生来说，识别出这一实体并进行治疗是至关重要的。目前已经有多种方法用于治疗 NSCC，包括广泛局部切除、指（趾）截断术、冷冻疗法、局部治疗和最近的 Mohs 显微外科手术（MMS）。
