Treps Lucas, Faure Sébastien, Clere Nicolas
Université de Nantes, CNRS, INSERM, CRCINA, F-44000 Nantes, France.
Micro et Nanomédecines Translationnelles, MINT, UNIV Angers, UMR INSERM 1066, UMR CNRS 6021, Angers, France.
Pharmacol Ther. 2021 Jul;223:107805. doi: 10.1016/j.pharmthera.2021.107805. Epub 2021 Jan 17.
Tumor cell vasculogenic mimicry (VM), also dubbed vascular mimicry, describes the plasticity of aggressive cancer cells forming de novo vascular networks and is associated with the malignant phenotype and poor clinical outcome. VM is described in a plethora of tumors, including carcinomas, sarcomas, glioblastomas, astrocytomas and melanomas. The presence of VM is associated with a high tumor grade, short survival, invasion and metastasis. A variety of molecular mechanisms and signal pathways participates in VM induction and formation. Due to VM's contribution on tumor progression, more VM-related strategies are being utilized for anticancer treatment. After describing the main features of VM, this review will outline the importance of the tumor microenvironment during this process, and highlight the predominant molecular targets and signaling pathways involved. These data will make it possible to discuss the importance of VM-associated mediators in antitumor therapy and how it could allow to better understand the resistance to anticancer therapy.
肿瘤细胞血管生成拟态（VM），也被称为血管拟态，描述了侵袭性癌细胞形成新生血管网络的可塑性，并且与恶性表型和不良临床结局相关。VM在大量肿瘤中都有描述，包括 carcinomas、肉瘤、胶质母细胞瘤、星形细胞瘤和黑色素瘤。VM的存在与高肿瘤分级、短生存期、侵袭和转移相关。多种分子机制和信号通路参与VM的诱导和形成。由于VM对肿瘤进展的作用，更多与VM相关的策略正被用于抗癌治疗。在描述了VM的主要特征之后，本综述将概述在此过程中肿瘤微环境的重要性，并突出所涉及的主要分子靶点和信号通路。这些数据将使得讨论VM相关介质在抗肿瘤治疗中的重要性以及它如何能有助于更好地理解对抗癌治疗的耐药性成为可能。
