Department of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008, Hunan, People's Republic of China.
Department of Oncology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.
J Hematol Oncol. 2020 Mar 14;13(1):19. doi: 10.1186/s13045-020-00858-6.
Distinct from classical tumor angiogenesis, vasculogenic mimicry (VM) provides a blood supply for tumor cells independent of endothelial cells. VM has two distinct types, namely tubular type and patterned matrix type. VM is associated with high tumor grade, tumor progression, invasion, metastasis, and poor prognosis in patients with malignant tumors. Herein, we discuss the recent studies on the role of VM in tumor progression and the diverse mechanisms and signaling pathways that regulate VM in tumors. Furthermore, we also summarize the latest findings of non-coding RNAs, such as lncRNAs and miRNAs in VM formation. In addition, we review application of molecular imaging technologies in detection of VM in malignant tumors. Increasing evidence suggests that VM is significantly associated with poor overall survival in patients with malignant tumors and could be a potential therapeutic target.
与经典的肿瘤血管生成不同，脉管生成拟态（VM）为肿瘤细胞提供了一种独立于内皮细胞的血液供应。VM 有两种不同的类型，即管状型和图案基质型。VM 与恶性肿瘤患者的高肿瘤分级、肿瘤进展、侵袭、转移和预后不良有关。在此，我们讨论了 VM 在肿瘤进展中的作用以及调节肿瘤中 VM 的多种机制和信号通路的最新研究。此外，我们还总结了非编码 RNA（如 lncRNA 和 miRNA）在 VM 形成中的最新发现。此外，我们回顾了分子成像技术在检测恶性肿瘤中 VM 的应用。越来越多的证据表明，VM 与恶性肿瘤患者的总体生存率显著相关，可能是一个潜在的治疗靶点。
