Liu Bide, Li Xun, Wang Shuheng, Jia Hongliang, Zhang Xiaoan, Dong Qiang, Li Jiuzhi
Department of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.
Department of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China; Laboratory of Urology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.
Transl Oncol. 2025 Jan;51:102155. doi: 10.1016/j.tranon.2024.102155. Epub 2024 Nov 1.
The incidence of prostate cancer (PCa) is increasing annually, making it the leading cause of tumor-related mortality in males. The available treatment options for metastatic PCa are limited. Vasculogenic mimicry (VM), an emerging phenomenon involving aggressive tumor cells, has a significant impact on patient survival. Misregulation of Wnt5a expression is commonly observed during cancer progression. However, there is a lack of comprehensive studies investigating the effects of Wnt5a on tumor VM formation. In this study, we demonstrate that alterations in wnt5a expression, either through gain or loss, have a significant influence on the formation of VM in tumor cells mediated by cell stemness and EMT progression. Further research has demonstrated that Wnt5a regulates the formation of VM through the PI3K/JNK signaling pathway. These experimental findings offer a novel avenue for the clinical management of prostate cancer.
前列腺癌（PCa）的发病率逐年上升，使其成为男性肿瘤相关死亡的主要原因。转移性PCa的现有治疗选择有限。血管生成拟态（VM）是一种涉及侵袭性肿瘤细胞的新现象，对患者生存有重大影响。在癌症进展过程中，通常会观察到Wnt5a表达失调。然而，缺乏全面研究来探究Wnt5a对肿瘤VM形成的影响。在本研究中，我们证明，通过增加或减少Wnt5a表达所引起的变化，对由细胞干性和上皮-间质转化（EMT）进程介导的肿瘤细胞中VM的形成有显著影响。进一步研究表明，Wnt5a通过PI3K/JNK信号通路调节VM的形成。这些实验结果为前列腺癌的临床治疗提供了一条新途径。
