Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, United States.
Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, United States.
Neurotoxicol Teratol. 2021 Mar-Apr;84:106955. doi: 10.1016/j.ntt.2021.106955. Epub 2021 Jan 16.
Many people undergo procedures requiring general anesthesia each day and adverse cognitive effects have been reported in response to that anesthesia. Postoperative Cognitive Dysfunction (POCD) may occur in as many as 80% of adults during the first post-surgical week and can have lasting effects. Here, the cognitive and motor effects of sevoflurane exposure in Sprague-Dawley rats was examined along with body weights, blood oxygen saturation, heart rate, and body temperature. Male and female rats were exposed to 2.5% sevoflurane or medical grade air for one hour at postnatal day 115. Beginning the following day, rats began a series of behavioral tests examining locomotor activity, motor coordination, novel object recognition, and spatial learning and memory in a water maze. Blood oxygen saturation, heart rate, and body temperature were not affected by the sevoflurane exposure. A slight effect on locomotor activity was detected, but no effects on motor coordination, novel object recognition, or spatial learning and memory were observed. Brain weights following behavioral testing did not differ. The results reported here along with existing literature suggest sevoflurane is largely without effects on later cognition in adult rodents when exposure is of a relatively short duration and at a relatively low concentration.
许多人每天都要接受需要全身麻醉的手术，而全身麻醉后会出现认知方面的不良反应。术后认知功能障碍（POCD）在术后第一周多达 80%的成年人中可能发生，且可能具有持久的影响。在此，研究人员检查了七氟醚暴露对 Sprague-Dawley 大鼠的认知和运动的影响，同时还检查了体重、血氧饱和度、心率和体温。雄性和雌性大鼠在出生后第 115 天接受 2.5%七氟醚或医用空气暴露 1 小时。从第二天开始，大鼠开始进行一系列行为测试，包括在水迷宫中检查运动活动、运动协调、新物体识别以及空间学习和记忆。七氟醚暴露并未影响血氧饱和度、心率和体温。虽然检测到对运动活动有轻微影响，但未观察到对运动协调、新物体识别或空间学习和记忆有影响。行为测试后的脑重没有差异。这里报告的结果以及现有文献表明，当暴露时间相对较短且浓度相对较低时，七氟醚对成年啮齿动物的后期认知基本没有影响。
