Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
Early Hum Dev. 2021 Mar;154:105309. doi: 10.1016/j.earlhumdev.2021.105309. Epub 2021 Jan 14.
To evaluate whether preterm infants with cerebral hemorrhage show alterations of aEEG signals in the first four weeks of life.
Preterm infants (n = 536) born before 32 completed weeks of pregnancy at Innsbruck Medical University Hospital were included in the study. AEEG recordings were evaluated for the Burdjalov score and cerebral hemorrhage was diagnosed by cerebral ultrasound.
Eighty preterm infants with cerebral hemorrhage (median gestational age 28.9 weeks, median birth weight 1157 g) and 456 preterm infants without cerebral hemorrhage (median gestational age 30.0 weeks, median birth weight 1300 g) were investigated. Burdjalov total scores were significantly lower in infants with cerebral hemorrhage. Infants with mild cerebral hemorrhage showed higher Burdjalov total scores compared to infants with severe cerebral hemorrhage in the first days of life. A Burdjalov total score of seven or more was predictive for no development of a cerebral hemorrhage, with a highest area under the curve (0.613) at postnatal day three.
Preterm infants with cerebral hemorrhage show alterations in aEEG signals in the newborn period. In future aEEG could be used as a supplemental method to monitor preterm infants at risk for cerebral hemorrhage. The use of aEEG in early life could reduce the number of ultrasound examinations and limit cumulative stress and discomfort in preterm infants.
评估脑出血早产儿在生命的前四周内是否存在脑电图（aEEG）信号改变。
本研究纳入了因胎龄小于 32 周而在因斯布鲁克医科大学附属医院出生的早产儿（n=536）。对 aEEG 记录进行 Burdjalov 评分评估，并通过脑超声诊断脑出血。
研究共纳入了 80 例脑出血早产儿（中位胎龄 28.9 周，中位出生体重 1157g）和 456 例无脑出血早产儿（中位胎龄 30.0 周，中位出生体重 1300g）。脑出血患儿的 Burdjalov 总评分明显较低。脑出血程度较轻的患儿在生命最初几天的 Burdjalov 总评分高于脑出血程度较重的患儿。Burdjalov 总评分达到 7 分或更高可预测无脑出血发生，出生后第 3 天的曲线下面积最大（0.613）。
脑出血早产儿在新生儿期存在脑电图信号改变。未来，aEEG 可作为一种补充方法来监测有脑出血风险的早产儿。在生命早期使用 aEEG 可以减少超声检查的次数，限制早产儿的累积应激和不适。
