Solution-gated graphene transistor based sensor for histamine detection with gold nanoparticles decorated graphene and multi-walled carbon nanotube functionalized gate electrodes.

In order to achieve accurate detection and evaluation of the freshness of fish samples, high sensitivity and selectivity of histamine sensors based on solution-gated graphene transistors (SGGT) have been successfully developed. By using graphene (Gra), multi-walled carbon nanotubes (MWNT) and gold nanoparticles (AuNP) to functionalize the gate electrode, the electrocatalytic performance of the device can be significantly improved. We have found that graphene, MWNT and AuNP modified SGGT sensors exhibit an ultra-low detection limit of 100 nM for histamine, a linear range of 3 μM-100 μM. We have also demonstrated that the SGGT-based histamine sensor has a high recovery rate and is capable of assessing the histamine content of actual fish samples in a fast and accurate manner. Considering the superior performance of the SGGT-based histamine sensor, it can be readily extended to histamine determination in many other real food samples for their freshness assessment.