Graduate Program in Physical Education, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Graduate Program in Physical Education, Universidade Federal do Paraná, Paraná, Brazil.
Gerontology. 2021;67(2):160-167. doi: 10.1159/000511910. Epub 2021 Jan 19.
Parkinson's disease (PD) leads to deficits in upper limb strength and manual dexterity and consequently resulting in functional impairment. Handgrip strength is correlated with the motor symptom severity of the disease, but there is a gap in the literature about the influence of freezing in PD patients.
The objective is to study the correlation between handgrip strength and motor symptom severity considering the freezing phenomenon and to verify variables that can predict Unified Parkinson's Disease Rating Scale (UPDRS) III.
This is a multicenter cross-sectional study in PD. 101 patients were divided into 2 groups: freezing of gait (FOG) (n = 51) and nonfreezing (nFOG) (n = 52). Freezing of Gait Questionnaire (FOGQ); UPDRS II and III sections; Hoehn and Yahr (HY) scale; handgrip dynamometry (HD); 9 Hole Peg Test (9-HPT) were assessed.
In both groups, HD was correlated to UPDRS III (nFOG: -0.308; FOG: -0.301), UPDRS total (nFOG: -0.379; FOG: -0.368), UPDRS item 23 (nFOG: -0.404; FOG: -0.605), and UPDRS item 24 (nFOG: -0.405; FOG: -0.515). For the correlation to UPDRS II (0.320) and 9-HPT (-0.323), only nFOG group presented significance. For the UPDRS 25 (-0.437), only FOG group presented statistical significance. The UPDRS III can be predicted by 9-HPT, age, and HY in nFOG patients (Adjusted R2 = 0.416). In FOG group, UPDRS III can be predicted by HD, 9-HPT, age, and HY (Adjusted R2 = 0.491).
Handgrip strength showed to be predictive of motor impairment only in the FOG group. Our results showed clinical profile differences of motor symptoms considering freezers and nonfreezers with PD.
帕金森病（PD）导致上肢力量和手灵巧度下降，进而导致功能障碍。手握力与疾病的运动症状严重程度相关，但在 PD 患者冻结现象方面的文献存在差距。
研究考虑冻结现象的手握力与运动症状严重程度之间的相关性，并验证可预测统一帕金森病评定量表（UPDRS）III 的变量。
这是一项 PD 的多中心横断面研究。101 名患者分为 2 组：冻结步态（FOG）组（n = 51）和非冻结步态（nFOG）组（n = 52）。采用冻结步态问卷（FOGQ）、UPDRS II 和 III 部分、Hoehn 和 Yahr（HY）量表、手握力测力计（HD）、9 孔钉测试（9-HPT）进行评估。
在两组中，HD 与 UPDRS III（nFOG：-0.308；FOG：-0.301）、UPDRS 总分（nFOG：-0.379；FOG：-0.368）、UPDRS 项目 23（nFOG：-0.404；FOG：-0.605）和 UPDRS 项目 24（nFOG：-0.405；FOG：-0.515）相关。与 UPDRS II（0.320）和 9-HPT（-0.323）的相关性仅在 nFOG 组有意义。对于 UPDRS 25（-0.437），仅 FOG 组有统计学意义。在 nFOG 患者中，UPDRS III 可由 9-HPT、年龄和 HY 预测（调整后的 R2 = 0.416）。在 FOG 组中，HD、9-HPT、年龄和 HY 可预测 UPDRS III（调整后的 R2 = 0.491）。
仅在 FOG 组中，手握力表现出对运动障碍的预测性。我们的研究结果表明，考虑到 PD 患者的冻结和非冻结，运动症状的临床特征存在差异。
