Toledano-Serrabona Jorge, Romeu-I-Fontanet Aleida, Gay-Escoda Cosme, Camps-Font Octavi, Sánchez-Garcés Mª Ángeles
Faculty of Medicine and Health Sciences, University of Barcelona; IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain.
School of Medicine and Health Sciences, University of Barcelona, Barcelona (Spain).
J Oral Implantol. 2022 Apr 1;48(2):158-167. doi: 10.1563/aaid-joi-D-20-00202.
The main objective of this study was to compare the clinical and histological results of synthetic bone substitutes used in maxillary sinus floor augmentation. A systematic review and meta-analysis was performed by searching the PubMed/MEDLINE, Scopus, and Cochrane databases for studies of the success of endosseous dental implant, implant failure, peri-implant marginal bone loss, newly formed bone, and residual bone graft material. After the search, 10 randomized clinical trials were included, with 4 studies ranging from low to unclear risk of bias were used for meta-analysis, comparing biphasic calcium phosphate (BCP) and deproteinized bovine bone (DBB). A greater amount of residual graft material (mean difference [MD]: -4.80 mm; 95% CI: -9.35 to -0.26; P = .040) was found in the DBB group. No other statistically significant differences were found between BCP and DBB for the remaining outcomes. Our results suggested that BCP can be considered a suitable alternative to DBB in maxillary sinus floor augmentation due to its clinical and histological results.
本研究的主要目的是比较在上颌窦底提升术中使用的合成骨替代物的临床和组织学结果。通过检索PubMed/MEDLINE、Scopus和Cochrane数据库，对关于骨内牙种植体成功、种植体失败、种植体周围边缘骨丢失、新形成骨以及残余骨移植材料的研究进行了系统评价和荟萃分析。检索后，纳入了10项随机临床试验，其中4项风险偏倚程度为低到不明确的研究用于荟萃分析，比较双相磷酸钙（BCP）和脱蛋白牛骨（DBB）。在DBB组中发现了更多的残余移植材料（平均差[MD]：-4.80 mm；95%可信区间：-9.35至-0.26；P = 0.040）。对于其余结果，BCP和DBB之间未发现其他统计学上的显著差异。我们的结果表明，由于其临床和组织学结果，在临床上BCP可被视为DBB在上颌窦底提升术中的合适替代品。
