Wang Yinan, Li Lin, Kotsuchibashi Yohei, Vshyvenko Sergey, Liu Yang, Hall Dennis, Zeng Hongbo, Narain Ravin
Department of Chemical and Materials Engineering, University of Alberta, 116 Street and 85 Avenue, Edmonton, Alberta T6G 2G6, Canada.
Department of Civil and Environmental Engineering, University of Alberta, 116 Street and 85 Avenue, Edmonton, Alberta T6G 2G6, Canada.
ACS Biomater Sci Eng. 2016 Dec 12;2(12):2315-2323. doi: 10.1021/acsbiomaterials.6b00527. Epub 2016 Oct 21.
Hydrogels containing sugar and oxaborole residues with remarkable self-healing properties were synthesized by free-radical polymerization in a facile and one pot process. The strong covalent interactions between the oxaborole residues and free adjacent hydroxyl groups of the pendent sugar residues of the glycopolymer allowed the formation of hydrogels achievable under either neutral or alkaline conditions. These hydrogels showed excellent self-healing and injectability behaviors in aqueous conditions and were found to be responsive to both pH and the presence of free sugars (such as glucose) in solution. Furthermore, these hydrogels can easily be reconstructed from their lyophilized powder into any desired three-dimensional scaffold. Additionally, the hydrogels can be designed to have very low cytotoxicity and hence can be used as a scaffold for cell encapsulation. With these unique properties, these biocompatible, biodegradable, rebuildable, and self-healable hydrogels offer great potential in many biomedical applications.
通过自由基聚合反应，以简便的一锅法合成了含有糖和硼酸酯残基且具有显著自愈性能的水凝胶。硼酸酯残基与糖聚合物侧链糖残基的游离相邻羟基之间的强共价相互作用使得在中性或碱性条件下都能形成水凝胶。这些水凝胶在水性条件下表现出优异的自愈和可注射性能，并且发现它们对溶液中的pH值和游离糖（如葡萄糖）的存在都有响应。此外，这些水凝胶可以很容易地从其冻干粉末重建为任何所需的三维支架。另外，这些水凝胶可以设计成具有非常低的细胞毒性，因此可以用作细胞封装的支架。凭借这些独特的性能，这些生物相容、可生物降解、可重建和可自愈的水凝胶在许多生物医学应用中具有巨大潜力。
