Abdul Karim Anis, Chee Pei Lin, Chan Meng Fai, Loh Xian Jun
Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, Singapore 138634.
Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore.
ACS Biomater Sci Eng. 2016 Dec 12;2(12):2185-2195. doi: 10.1021/acsbiomaterials.6b00383. Epub 2016 Nov 9.
The fabrication of supramolecular hydrogels from micellized PLLA/DMAEMA/PEGMA polymers with α-CD has been explored to design injectable gel formulations for sustained drug release. The tricomponent hydrogels (5% w/v)/α-CD (10% w/v) were able to sustain protein (BSA and lysozyme) release for 60-120 h at different pH conditions (pH 3, 7 and 10). In-depth rheological analysis highlighted the role of pH in tuning hydrogel behavior upon shear at microscopic level affecting protein release profiles. Protein release involved complex interactions within the network (isoelectric point and diffusion coefficient of the protein, p of DMAEMA, and pore size of the hydrogel). Lissajous-Bowditch curves explained the microstructural response to increasing strain which weakened the supramolecular association and collapsed the formation of the porous hydrogel. Power Law was adopted to represent both transport mechanism and drug release phenomena. The release mechanism resulted from a combination of erosion- and diffusion-controlled release (non-Fickian and super case II).
已探索了由胶束化的聚乳酸/甲基丙烯酸二甲氨基乙酯/聚甲基丙烯酸乙二醇酯聚合物与α-环糊精制备超分子水凝胶，以设计用于药物持续释放的可注射凝胶制剂。三组分水凝胶（5% w/v）/α-环糊精（10% w/v）能够在不同pH条件（pH 3、7和10）下持续释放蛋白质（牛血清白蛋白和溶菌酶）60至120小时。深入的流变学分析突出了pH在微观水平调节水凝胶在剪切作用下的行为对蛋白质释放曲线的影响。蛋白质释放涉及网络内的复杂相互作用（蛋白质的等电点和扩散系数、甲基丙烯酸二甲氨基乙酯的p值以及水凝胶的孔径）。李萨如曲线解释了微观结构对增加应变的响应，这削弱了超分子缔合并破坏了多孔水凝胶的形成。采用幂律来表示传输机制和药物释放现象。释放机制是由侵蚀控制释放和扩散控制释放（非菲克扩散和超级Ⅱ型）相结合导致的。
