肝硬化患者中由产超广谱β-内酰胺酶细菌引起的血流感染
Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing in Patients with Liver Cirrhosis.
作者信息
Chen Wen-Chi, Hung Chih-Hsin, Chen Yao-Shen, Cheng Jin-Shiung, Lee Susan Shin-Jung, Tseng Fan-Chen, Cheng Ming-Fang, Wang Jiun-Ling
机构信息
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
Department of Chemical Engineering and Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung 840, Taiwan.
出版信息
Pathogens. 2021 Jan 5;10(1):37. doi: 10.3390/pathogens10010037.
BACKGROUND
This study aimed to investigate the frequency of sequence type (ST) 131 strains and outcome of cirrhotic patients with bloodstream infections (BSIs) caused by extended-spectrum beta-lactamase-producing (ESBLEC) and non-extended-spectrum beta-lactamase-producing (NESBLEC).
METHODS
The incidence of ST 131 strains, hospital stay, and 30-day re-admission/mortality were compared between 51 ESBLEC and 51 NESBLEC bacteremic patients with cirrhosis.
RESULTS
ST 131 strains were found in 35.3% of the ESBLEC group and 0% of the NESBLEC group ( < 0.001). Mean hospital stay was 26.5 days in the ESBLEC group and 17.1 days in the NESBLEC group ( = 0.006). Thirty-day re-admission rates were 11.8% in the ESBLEC group and 5.9% in the NESBLEC group ( = 0.5). ST 131 strains were associated with 30-day re-admission (odds ratio: 4.5, 95% confidence interval: 1.1-18.9). Thirty-day mortality rate was 31.4% in the ESBLEC group and 23.5% in the NESBLEC group ( = 0.4).
CONCLUSION
In patients with cirrhosis, the ESBLEC BSIs group had a higher frequency of ST 131 strains and longer hospital stay than the NESBLEC BSIs group with similar 30-day re-admission/mortality. ST 131 strains were associated with 30-day re-admission.
背景
本研究旨在调查序列类型（ST）131菌株的频率，以及由产超广谱β-内酰胺酶（ESBLEC）和非产超广谱β-内酰胺酶（NESBLEC）引起的肝硬化血流感染（BSI）患者的预后。
方法
比较51例ESBLEC菌血症肝硬化患者和51例NESBLEC菌血症肝硬化患者中ST 131菌株的发生率、住院时间和30天再入院率/死亡率。
结果
ESBLEC组中35.3%发现ST 131菌株，NESBLEC组中未发现（P<0.001）。ESBLEC组平均住院时间为26.5天，NESBLEC组为17.1天（P = 0.006）。ESBLEC组30天再入院率为11.8%，NESBLEC组为5.9%（P = 0.5）。ST 131菌株与30天再入院相关（比值比：4.5，95%置信区间：1.1-18.9）。ESBLEC组30天死亡率为31.4%，NESBLEC组为23.5%（P = 0.4）。
结论
在肝硬化患者中，ESBLEC BSI组的ST 131菌株频率高于NESBLEC BSI组，住院时间更长，而30天再入院率/死亡率相似。ST 131菌株与30天再入院相关。
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