Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11010 Belgrade, Serbia.
Molecules. 2021 Jan 14;26(2):411. doi: 10.3390/molecules26020411.
This study investigates the modification of commercial cellulose acetate microfiltration membranes by supercritical solvent impregnation with thymol to provide them with antibacterial properties. The impregnation process was conducted in a batch mode, and the effect of pressure and processing time on thymol loading was followed. The impact of the modification on the membrane's microstructure was analyzed using scanning electron and ion-beam microscopy, and membranes' functionality was tested in a cross-flow filtration system. The antibiofilm properties of the obtained materials were studied against and , while membranes' blocking in contact with bacteria was examined for and . The results revealed a fast impregnation process with high thymol loadings achievable after just 0.5 h at 15 MPa and 20 MPa. The presence of 20% of thymol provided strong antibiofilm properties against the tested strains without affecting the membrane's functionality. The study showed that these strong antibacterial properties could be implemented to the commercial membranes' defined polymeric structure in a short and environmentally friendly process.
本研究通过超临界溶剂浸渍法对商业醋酸纤维素微滤膜进行改性，用麝香草酚赋予其抗菌性能。浸渍过程采用间歇式操作，跟踪压力和处理时间对麝香草酚负载量的影响。采用扫描电子和离子束显微镜分析了改性对膜微观结构的影响，并在错流过滤系统中测试了膜的功能。研究了所得材料对 和 的抗生物膜性能，以及与细菌接触时 和 的膜堵塞情况。结果表明，在 15 MPa 和 20 MPa 下仅 0.5 小时即可实现快速浸渍过程，并可实现高麝香草酚负载量。20%的麝香草酚的存在提供了针对测试菌株的强大抗生物膜性能，而不会影响膜的功能。研究表明，可以在短时间内通过环保的工艺将这些强大的抗菌性能应用于商业膜的特定聚合物结构。
