Kohler J, Heilmeyer H, Volk B
Abteilung Klinische Neurologie und Neurophysiologie, Albert-Ludwigs-Universität, Freiburg, FRG.
J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):281-4. doi: 10.1136/jnnp.51.2.281.
Two patients with multiple sclerosis are reported in whom psychopathological symptoms were present for many years. An exact psychiatric classification of the clinical syndrome was not possible. At no time during the illness were abnormal neurological findings observed. Multiple sclerosis was proven following necropsy in one patient. In the second patient a possible diagnosis of multiple sclerosis was made. This patient was found to have multiple lesions in the white matter which were evident on MRI and in the isoelectric focusing (IEF) of cerebrospinal fluid oligoclonal bands were found.
报告了两名患有多发性硬化症的患者，他们存在精神病理症状已多年。无法对临床综合征进行确切的精神科分类。在病程中的任何时候均未观察到异常的神经系统体征。其中一名患者在尸检后证实为多发性硬化症。在第二名患者中作出了多发性硬化症的可能诊断。该患者被发现白质中有多个病灶，在磁共振成像（MRI）上很明显，并且在脑脊液寡克隆带的等电聚焦（IEF）中也发现了这些病灶。
