Logsdail S J, Callanan M M, Ron M A
National Hospital for Nervous Diseases, London.
Psychol Med. 1988 May;18(2):355-64. doi: 10.1017/s003329170000790x.
This study reports the psychiatric morbidity in 76 patients with clinically isolated lesions of the type seen in multiple sclerosis (optic neuritis, brain stem and cord lesions). The presence or absence of brain pathology was investigated using magnetic resonance imaging (MRI). A group of 33 patients suffering from rheumatic and neurological conditions not known to involve the brain was used for comparison. Normative MRI data were obtained from a group of 40 normal volunteers. Over half of the patients with the clinical presentation of single lesions had MRI abnormalities in the brain, but past and present psychiatric morbidity were similar in patients and controls and no significant associations were found between the presence of MRI abnormalities and psychiatric morbidity. The degree of social stress experienced by the patients with clinically isolated lesions appeared to be highly relevant in the causation of psychiatric symptoms.
本研究报告了76例患有多发性硬化症中所见类型的临床孤立性病变（视神经炎、脑干和脊髓病变）患者的精神疾病发病率。使用磁共振成像（MRI）研究脑病理的有无。一组33例患有已知不涉及脑部的风湿性和神经疾病的患者用作对照。从40名正常志愿者中获取了规范性MRI数据。超过一半临床表现为单一病变的患者脑部存在MRI异常，但患者和对照组过去和现在的精神疾病发病率相似，且未发现MRI异常与精神疾病发病率之间存在显著关联。临床孤立性病变患者所经历的社会压力程度似乎与精神症状的病因高度相关。
