van Beers Joyce J B C, Damoiseaux Jan G M C
Central Diagnostic Laboratory Maastricht University Medical Center, Laboratory Specialist in Medical Immunology and Clinical Chemistry, 6202 AZ Maastricht, The Netherlands.
Central Diagnostic Laboratory Maastricht University Medical Center, Laboratory Specialist in Medical Immunology, 6202 AZ Maastricht, The Netherlands.
Biomolecules. 2021 Jan 16;11(1):116. doi: 10.3390/biom11010116.
Over the years, a wide variety of therapeutic antibodies has been successfully introduced in the auto-immunology clinic, and many more are on the way. Many of these treatments address either a pathogenic circulating molecule or a cell-bound molecule. Whereas addressing the former target results in neutralization of the soluble factor and binding to the latter target either inhibits cellular function or induces selective cell death. If this targeted molecule or cell is part of the immune system, this therapy evokes a state of immunodeficiency with infections as a possible consequence. Therefore, immune monitoring is needed to prevent such adverse side effects of immunotherapy. In this paper, different immunotherapies used in Sjögren's syndrome, as well as different approaches to monitoring the immune system, are discussed.
多年来，多种治疗性抗体已成功引入自身免疫病临床，还有更多正在研发中。这些治疗方法大多针对致病性循环分子或细胞结合分子。针对前者靶点会导致可溶性因子中和，而与后者靶点结合则会抑制细胞功能或诱导选择性细胞死亡。如果这种靶向分子或细胞是免疫系统的一部分，这种疗法会引发免疫缺陷状态，可能导致感染。因此，需要进行免疫监测以预防免疫治疗的此类不良副作用。本文讨论了干燥综合征中使用的不同免疫疗法以及监测免疫系统的不同方法。
