Department of Pediatrics, School of Medicine, Fukushima Medical University, Fukushima 9601295, Japan.
Molecules. 2021 Jan 15;26(2):427. doi: 10.3390/molecules26020427.
Subacute sclerosing panencephalitis (SSPE) is a late-onset, intractable, and fatal viral disease caused by persistent infection of the central nervous system by a mutant strain of the measles virus. Ribavirin intracerebroventricular therapy has already been administered to several SSPE patients in Japan based on fundamental and clinical research findings from our group, with positive therapeutic effects reported in some patients. However, the efficacy of this treatment approach has not been unequivocally established. Hence, development of more effective therapeutic methods using new antiviral agents is urgently needed. This review describes the current status of SSPE treatment and research, highlighting promising approaches to the development of more effective therapeutic methods.
亚急性硬化性全脑炎（SSPE）是一种迟发性、难治性和致命的病毒病，由麻疹病毒的突变株持续感染中枢神经系统引起。根据我们小组的基础和临床研究结果，日本已经对几名 SSPE 患者进行了利巴韦林脑室内治疗，一些患者的治疗效果报告为阳性。然而，这种治疗方法的疗效尚未得到明确证实。因此，迫切需要使用新的抗病毒药物开发更有效的治疗方法。本文综述了 SSPE 的治疗和研究现状，强调了开发更有效的治疗方法的有希望的方法。
