De Pinto Vito
Department of Biomedicine and Biotechnology Sciences, University of Catania, Via S. Sofia 64, 95123 Catania, Italy.
we.MitoBiotech.srl, c.so Italia 172, 95129 Catania, Italy.
Biomolecules. 2021 Jan 15;11(1):107. doi: 10.3390/biom11010107.
It has become impossible to review all the existing literature on Voltage-Dependent Anion selective Channel (VDAC) in a single article. A real Renaissance of studies brings this protein to the center of decisive knowledge both for cell physiology and therapeutic application. This review, after highlighting the similarities between the cellular context and the study methods of the solute carriers present in the inner membrane and VDAC in the outer membrane of the mitochondria, will focus on the isoforms of VDAC and their biochemical characteristics. In particular, the possible reasons for their evolutionary onset will be discussed. The variations in their post-translational modifications and the differences between the regulatory regions of their genes, probably the key to understanding the current presence of these genes, will be described. Finally, the situation in the higher eukaryotes will be compared to that of yeast, a unicellular eukaryote, where there is only one active isoform and the role of VDAC in energy metabolism is better understood.
要在一篇文章中综述所有关于电压依赖性阴离子选择性通道（VDAC）的现有文献已变得不可能。研究的真正复兴使这种蛋白质成为细胞生理学和治疗应用关键知识的核心。本综述在强调线粒体内膜中溶质载体与线粒体外膜中VDAC的细胞背景和研究方法之间的相似性之后，将聚焦于VDAC的同工型及其生化特性。特别是，将讨论它们进化出现的可能原因。将描述它们翻译后修饰的变化以及其基因调控区域之间的差异，这可能是理解这些基因当前存在情况的关键。最后，将高等真核生物的情况与酵母（一种单细胞真核生物）的情况进行比较，在酵母中只有一种活性同工型，并且VDAC在能量代谢中的作用得到了更好的理解。
