Arai Ayako
Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan.
Department of Hematological Therapeutics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8510, Japan.
Microorganisms. 2021 Jan 15;9(1):180. doi: 10.3390/microorganisms9010180.
Chronic active Epstein-Barr virus infection (CAEBV) is a disease where Epstein-Barr virus (EBV)-infected T- or NK-cells are activated and proliferate clonally. The symptoms of this dual-faced disease include systemic inflammation and multiple organ failures caused by the invasion of infected cells: inflammation and neoplasm. At present, the only effective treatment strategy to eradicate EBV-infected cells is allogeneic stem cell transplantation. Lately, the investigation into the disease's pathogenic mechanism and pathophysiology has been advancing. In this review, I will evaluate the new definition in the 2017 WHO classification, present the advancements in the study of CAEBV, and unfold the future direction.
慢性活动性EB病毒感染（CAEBV）是一种疾病，其中EB病毒（EBV）感染的T细胞或NK细胞被激活并克隆性增殖。这种双面疾病的症状包括由感染细胞入侵引起的全身炎症和多器官衰竭：炎症和肿瘤。目前，根除EBV感染细胞的唯一有效治疗策略是异基因干细胞移植。最近，对该疾病致病机制和病理生理学的研究一直在推进。在这篇综述中，我将评估2017年世界卫生组织分类中的新定义，介绍CAEBV研究的进展，并展望未来方向。
