人类 () 中的遗传变异与溃疡性的伯氏疏螺旋体溃疡有关。
Genetic variants in human () are associated with ulcerative forms of Buruli ulcer.
机构信息
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho Braga, Portugal.
ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
出版信息
Emerg Microbes Infect. 2021 Dec;10(1):223-225. doi: 10.1080/22221751.2021.1878936.
Abstract
Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the gene). We here report the association of genetic variants in with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further investigation on the implementation of novel methods for earlier identification of at-risk patients.
摘要
布鲁里溃疡（BU）是一种严重的皮肤分枝杆菌感染，其特征是广泛的细胞死亡，先前有研究表明，这种细胞死亡是由 Bcl2 样蛋白 11（BIM，由 基因编码）介导的。我们在此报告了在 618 名贝宁个体的队列中， 基因的遗传变异与溃疡性疾病的关联。我们的研究结果表明，人类凋亡的调控可能与预后较差的 BU 病变有关，这促使我们进一步研究新的方法，以便更早地识别高危患者。
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