Internal Medicine Department, Limoges University Hospital, 16 rue du Professeur Bernard Descottes, 87042, Limoges, France.
EA 3842 - Cellular Homeostasis and Diseases, Faculty of Medicine, University of Limoges, 2 rue du Docteur Marcland, 87025, Limoges, France.
Adv Rheumatol. 2021 Jan 19;61(1):5. doi: 10.1186/s42358-021-00164-w.
Abdominal symptoms in patients with primary Sjögren syndrome (pSS) are poorly documented. The objective of the study was to describe the abdominal symptoms of patients with pSS and to assess their association with characteristics of the disease.
One hundred and fifty patients with pSS were evaluated using a composite global symptom score for abdominal symptoms and their severity. Data concerning the clinical and biological characteristics of pSS and abdominal disorders were also collected.
Of the patients with pSS, 95% suffered from abdominal symptoms (median global symptom score 7.5 ± 5.5 points out of 30). More than half of the patients experienced abdominal tension (68%), upper abdominal pain (54%), abdominal discomfort (58%) and/or constipation (54%). Regarding the pSS activity, in relation to European League Against Rheumatism (EULAR) Sjögren syndrome disease activity index score items, general and central nervous system involvement wereassociated with a high global symptom score. The EULAR Sjogren Syndrome Patient Reported Index (ESSPRI) symptom score was positively correlated with the global symptom score (p < 0.01). Multivariate analysis showed a significant association between a high global symptom score and SSA seronegativity, gastroparesis, and ESSPRI score (p < 0.01 for each).
The majority of patients with pSS suffered abdominal symptoms. There is currently no therapeutic recommendation because of the lack of information on the underlying pathophysiological mechanisms.
NCT03157011 . Date of registration: July 17, 2017.
原发性干燥综合征（pSS）患者的腹部症状记录不佳。本研究的目的是描述 pSS 患者的腹部症状，并评估其与疾病特征的关系。
使用综合腹部症状整体症状评分和严重程度对 150 例 pSS 患者进行评估。还收集了与 pSS 和腹部疾病相关的临床和生物学特征的数据。
在 pSS 患者中，95%的患者有腹部症状（30 分中中位数整体症状评分为 7.5±5.5 分）。超过一半的患者有腹部紧张（68%）、上腹痛（54%）、腹部不适（58%）和/或便秘（54%）。关于 pSS 活动度，与欧洲抗风湿病联盟（EULAR）干燥综合征疾病活动指数评分项目相关，全身和中枢神经系统受累与高整体症状评分相关。EULAR 干燥综合征患者报告指数（ESSPRI）症状评分与整体症状评分呈正相关（p<0.01）。多变量分析显示，高整体症状评分与 SSA 阴性、胃轻瘫和 ESSPRI 评分之间存在显著相关性（p<0.01）。
大多数 pSS 患者有腹部症状。由于缺乏潜在病理生理机制的信息，目前尚无治疗建议。
NCT03157011。注册日期：2017 年 7 月 17 日。
