Wheat Health, Genetics, and Quality Research Unit, Agriculture Research Service, U.S. Department of Agriculture, Pullman, WA 99163, USA; Department of Crop and Soil Science, Washington State University, Pullman, WA 99163, USA.
BioDiscovery Institute, Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA.
Trends Plant Sci. 2021 Jul;26(7):720-728. doi: 10.1016/j.tplants.2020.12.012. Epub 2021 Jan 16.
N-Acylethanolamine (NAE) signaling has received considerable attention in vertebrates as part of the endocannabinoid signaling system, where anandamide acts as a ligand for G protein-coupled cannabinoid receptors. Recent studies indicate that G proteins also are required for some types of NAE signaling in plants. The genetic ablation of the Gβγ dimer or loss of the full set of extra-large G proteins strongly attenuated NAE-induced chloroplast responses in seedlings. Intriguing parallels and distinct differences have emerged between plants and animals in NAE signaling, despite the conserved use of these lipid mediators to modulate cellular processes. Here we compare similarities and differences and identify open questions in a fundamental lipid signaling pathway in eukaryotes with components that are both conserved and diverged in plants.
N-酰基乙醇胺（NAE）信号在脊椎动物中受到了相当多的关注，它是内源性大麻素信号系统的一部分，其中大麻素配体作用于 G 蛋白偶联大麻素受体。最近的研究表明，G 蛋白也需要在植物中进行某些类型的 NAE 信号传递。Gβγ二聚体的遗传缺失或超大 G 蛋白的全部缺失强烈减弱了幼苗中 NAE 诱导的叶绿体反应。尽管这些脂质介体被保守地用于调节细胞过程，但在 NAE 信号传递中，植物和动物之间出现了有趣的相似之处和明显的差异。在这里，我们比较了相似性和差异，并确定了在真核生物中具有保守和分化成分的基本脂质信号通路中的开放性问题。
