Gu Zhoupeng, Huang Yan, Yang Fengjie, Tang Shiqi, Sun Juan, Chen Tianru, Liu Fang, Wu Hong, Wang Jianwen
Department of Nephropathy, Third Xiangya Hospital of Central South University, 410013 Changsha, Hunan Province, China.
Department of Nephropathy, Third Xiangya Hospital of Central South University, 410013 Changsha, Hunan Province, China; Department of anesthesiology, Third Xiangya Hospital of Central South University, 410013 Changsha, Hunan Province, China.
Nephrol Ther. 2021 Feb;17(1):35-41. doi: 10.1016/j.nephro.2020.10.006. Epub 2021 Jan 17.
To investigate the role of neutrophil gelatinase-associated lipocalin in the evaluation of renal function, nutrition, anemia and inflammation in patients with chronic kidney diseases.
A total of 302 patients with chronic kidney diseases were selected, and their clinical data, blood neutrophil gelatinase-associated lipocalin levels, renal function, nutrition, anemia, inflammation and calcium, and phosphorus metabolism were analyzed.
Serum neutrophil gelatinase-associated lipocalin level increased with the progression of chronic kidney diseases. Higher neutrophil gelatinase-associated lipocalin levels were observed in patients with chronic kidney diseases stage 3b compared with healthy individuals (P<0.05), while the patients with chronic kidney diseases stage 5 showed higher levels compared with other chronic kidney diseases stages (P<0.01). Moreover, the ROC curve showed that neutrophil gelatinase-associated lipocalin had a better diagnostic performance from the chronic kidney diseases stage 3b to 5 (P<0.05). In addition, the serum neutrophil gelatinase-associated lipocalin levels in patient with chronic kidney diseases were negatively correlated with body mass index, number of red blood cells, hemoglobin, transferrin, the estimatedglomerular filtration rate (eGFR), serum calcium (P<0.01); and were positively correlated with mean arterial blood pressure, blood BUN, SCr and alpha 1 microglobulin, beta 2 microglobulin, urinary inhibition C, homocysteine, PTH levels, neutrophils ratio, free serum ferritin and c-reactive protein (P<0.01); while no significant correlation was found with gender, and age (P>0.05).
Serum neutrophil gelatinase-associated lipocalin levels are closely related to renal function injury, inflammatory response and anemia-related indicators in patients with chronic kidney diseases, and thus could be used as a diagnostic biomarker for evaluating the degree of renal injury and related complications in patients with chronic kidney diseases.
探讨中性粒细胞明胶酶相关脂质运载蛋白在评估慢性肾脏病患者肾功能、营养状况、贫血及炎症反应中的作用。
选取302例慢性肾脏病患者，分析其临床资料、血液中性粒细胞明胶酶相关脂质运载蛋白水平、肾功能、营养状况、贫血、炎症反应以及钙磷代谢情况。
血清中性粒细胞明胶酶相关脂质运载蛋白水平随慢性肾脏病病情进展而升高。与健康个体相比，慢性肾脏病3b期患者中性粒细胞明胶酶相关脂质运载蛋白水平更高（P<0.05）；与其他慢性肾脏病分期相比，慢性肾脏病5期患者该水平更高（P<0.01）。此外，ROC曲线显示，中性粒细胞明胶酶相关脂质运载蛋白在慢性肾脏病3b期至5期具有较好的诊断效能（P<0.05）。另外，慢性肾脏病患者血清中性粒细胞明胶酶相关脂质运载蛋白水平与体重指数、红细胞计数、血红蛋白、转铁蛋白、估算肾小球滤过率（eGFR）、血清钙呈负相关（P<0.01）；与平均动脉压、血尿素氮、血肌酐、α1微球蛋白、β2微球蛋白、尿抑制素C、同型半胱氨酸、甲状旁腺激素水平、中性粒细胞比例、血清游离铁蛋白及C反应蛋白呈正相关（P<0.01）；与性别、年龄无显著相关性（P>0.05）。
慢性肾脏病患者血清中性粒细胞明胶酶相关脂质运载蛋白水平与肾功能损伤、炎症反应及贫血相关指标密切相关，可作为评估慢性肾脏病患者肾损伤程度及相关并发症的诊断生物标志物。
