[术前化疗对晚期结直肠癌的临床意义]

[Clinical Significance of Preoperative Chemotherapy for Advanced Colorectal Cancer].

作者信息

Tachimori Akiko, Yonemitsu Ken, Fukui Yasuhiro, Tashima Tetsuzo, Nishimura Junya, Aomatsu Naoki, Nishii Takafumi, Murata Akihiro, Kodai Shintaro, Sakurai Katsunobu, Tamamori Yutaka, Kubo Naoshi, Shimizu Sadatoshi, Kanazawa Akishige, Maeda Kiyoshi

机构信息

Dept. of Gastroenterological Surgery, Osaka City General Hospital.

出版信息

Gan To Kagaku Ryoho. 2020 Dec;47(13):2021-2023.

PMID:33468787

Abstract

We examined 22 cases who underwent preoperative chemotherapy in our hospital from 2013 April to 2018 December. Seven patients were treated as neoadjuvant chemotherapy(NAC). Out of 15 patients with unresectable diseases before chemotherapy, 6 patients were able to R0 resection after chemotherapy(conversion). Although only one patients was underwent RM1 resection, the other patients were underwent RM0 resection. The median overall survival was 42 months in NAC group, 28 months in conversion group, and 17 months in palliative resection group, respectively. Recurrence was observed in 1 patient in NAC group, however, all patients had recurrent disease in conversion group. In this study, although further examination should be done according to the clinical significance of preoperative chemotherapy, preoperative chemotherapy may be carried out without severe adverse event and severe postoperative complication.

摘要

我们研究了2013年4月至2018年12月在我院接受术前化疗的22例患者。7例患者接受新辅助化疗（NAC）。在化疗前无法切除的15例患者中，6例患者化疗后能够进行R0切除（转化）。虽然只有1例患者接受了RM1切除，但其他患者接受了RM0切除。NAC组的中位总生存期分别为42个月，转化组为28个月，姑息切除组为17个月。NAC组有1例患者出现复发，然而，转化组所有患者均出现疾病复发。在本研究中，虽然应根据术前化疗的临床意义进行进一步检查，但术前化疗可能在无严重不良事件和严重术后并发症的情况下进行。