Kuze Manami, Negishi Kazuno, Koyasu Toshiyuki, Kondo Mineo, Tsubota Kazuo, Ayaki Masahiko
Division of Ophthalmology, Matsusaka Central General Hospital, Matsusaka, Japan.
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Sci Rep. 2021 Jan 19;11(1):1828. doi: 10.1038/s41598-020-79751-8.
We evaluated the pupil reaction to blue and white light stimulation in 70 eyes with cataract and in 38 eyes with a selective blue-light filtering intra-ocular lens. The diameter of the pupil before stimulation was set as baseline (BPD) and, after a stimulus duration of 1 s, the post-illumination pupillary response (PIPR) was measured using an electronic pupillometer. The BPD showed no significant difference among three grades of nuclear sclerosis (NS). In contrast, the PIPRs differed significantly among the NS grades eyes including with and without subcapsular cataract (SC) and IOL eyes for white light (p < 0.05, Kruskal-Wallis test), but not for blue light. Subcapsular opacity did not affect the BPD or PIPR in all cataract grades for either light stimulus. The tendency of larger PIPR in the pseudophakic eyes than the cataract eyes for both lights, however significant difference was found only for white light (p < 0.05 for white light, p > 0.05 for blue light). Our study demonstrates retention of the PIPR for blue light, but not for white light in cataract eyes. We also confirmed that the pupillary response in pseudohakic eyes with a selective blue light-filtering intra ocular lens was greater than that in cataractous eyes for white light.
我们评估了70只白内障患眼和38只植入选择性蓝光滤过型人工晶状体患眼对蓝光和白光刺激的瞳孔反应。刺激前的瞳孔直径设为基线值（BPD），在1秒的刺激持续时间后，使用电子瞳孔计测量光照后瞳孔反应（PIPR）。BPD在核硬度（NS）的三个等级之间无显著差异。相比之下，NS等级的患眼中，包括有或无后囊下白内障（SC）的患眼以及植入人工晶状体的患眼，白光刺激下的PIPR有显著差异（p < 0.05，Kruskal-Wallis检验），但蓝光刺激下无显著差异。后囊下混浊对所有白内障等级的两种光刺激下的BPD或PIPR均无影响。然而，两种光刺激下，人工晶状体眼的PIPR均有大于白内障眼的趋势，不过仅在白光刺激下差异有统计学意义（白光p < 0.05，蓝光p > 0.05）。我们的研究表明，白内障患眼对蓝光刺激保留了PIPR，但对白光刺激则没有。我们还证实，植入选择性蓝光滤过型人工晶状体的人工晶状体眼对白光的瞳孔反应大于白内障患眼。
