Steeg P S, Bevilacqua G, Kopper L, Thorgeirsson U P, Talmadge J E, Liotta L A, Sobel M E
Division of Cancer Biology and Diagnosis, National Cancer Institute, Bethesda, MD 20892.
J Natl Cancer Inst. 1988 Apr 6;80(3):200-4. doi: 10.1093/jnci/80.3.200.
We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identified, and (2) N-nitroso-N-methylurea-induced rat mammary carcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsic aggressiveness. The predicted carboxy-terminal protein sequence encoded by the pNM23 cDNA clone is novel compared with Genebank animal, bacterial, and viral sequences.
我们描述了一种与肿瘤转移过程相关的基因NM23。在两个实验系统中，NM23 RNA水平在转移潜能相对较低的细胞和肿瘤中最高：(1) 鉴定出该基因的小鼠K-1735黑色素瘤细胞系，以及(2) N-亚硝基-N-甲基脲诱导的大鼠乳腺癌。NM23 RNA水平与细胞对宿主免疫反应的敏感性无关，因此可能与内在侵袭性有关。与基因库中的动物、细菌和病毒序列相比，pNM23 cDNA克隆编码的预测羧基末端蛋白质序列是新的。
