Sharar S R, Heimbach D M, Howard M, Hildebrandt J, Winn R K
Department of Surgery, University of Washington School of Medicine, Seattle.
J Trauma. 1988 Feb;28(2):164-70. doi: 10.1097/00005373-198802000-00006.
In the majority of clinical cases, smoke inhalation results in a self-limited lung injury mostly confined to the airways. In this study, an animal model of inhalation injury was developed that reflected similar pathophysiology. Cardiopulmonary parameters were studied in awake, instrumented goats following spontaneous inhalation of characterized Douglas fir smoke. Peak carboxyhemoglobin levels averaged 37% during a mean exposure time of 33 minutes. All animals survived the 24-hour study period, and showed only transient abnormalities in lung fluid balance and gas exchange, with no change in lung mechanics or plasma eicosanoid (TxB2 and 6-keto-PGF1 alpha) levels. However, extravascular lung water at 24 hours was increased 33%, suggesting the presence of some airway edema and retained secretions. We feel this model fairly represents the majority of clinical smoke inhalation cases. This model is compared to other large animal inhalation injury models producing more severe lung injury.
在大多数临床病例中，烟雾吸入导致的肺损伤多为自限性，主要局限于气道。在本研究中，建立了一种反映相似病理生理学的吸入性损伤动物模型。对清醒的、已安装仪器的山羊在自主吸入经鉴定的花旗松烟雾后进行心肺参数研究。在平均暴露时间33分钟内，碳氧血红蛋白峰值水平平均为37%。所有动物均存活至24小时研究期结束，仅在肺液体平衡和气体交换方面出现短暂异常，肺力学或血浆类花生酸（TxB2和6-酮-PGF1α）水平无变化。然而，24小时时血管外肺水增加了33%，提示存在一些气道水肿和分泌物潴留。我们认为该模型相当代表了大多数临床烟雾吸入病例。将该模型与其他导致更严重肺损伤的大型动物吸入性损伤模型进行了比较。
