Mohamed Osman Nasr Mohamed, Abdel Kader Moustafa, Aziz Nasr Taghreed A E L, Sharawy Mohamed Ahmed, Keryakos Hesham Kamal Habeeb
Radiology Department, Faculty of Medicine, Minia University, El Minia, Egypt.
Internal Medicine Department, Faculty of Medicine, Minia University, El Minia, Egypt.
Int J Nephrol Renovasc Dis. 2021 Jan 11;14:1-10. doi: 10.2147/IJNRD.S254022. eCollection 2021.
Diabetic kidney disease is the most common cause of ESRD. There is poor correlation between the degree of renal fibrosis and current screening markers. A noninvasive imaging technique is needed to assess the degree of structural changes in the kidney. The aim of this study was to assess the role of apparent diffusion coefficient (ADC) in the diagnosis of diabetic kidney disease. Forty adult diabetic patients with chronic kidney disease as well as 20 age- and sex-matched adult healthy controls were recruited from Nephrology Department of our University Hospital. All patients underwent renal MR-DWI and ADC mapping on a 1.5-T scanner (Philips Achieva) using phased array body coil.
Among the studied 40 diabetic patients, five groups of patients were resulted 8 patients for each and the ADC values were inversely correlated with advancement in renal parenchymal affection, ie, in late stages of the disease the ADC values were lower than in early stages. The mean ADC values of renal parenchyma in patients with diabetic kidney disease were considerably lower than that of healthy controls with normal renal function (2.1±0.3x10 mm/s vs 2.4±0.1x10 mm/s with <0.001).
ADC value is a possible noninvasive technique in evaluating the stage of renal dysfunction with assessment of disease progression.
糖尿病肾病是终末期肾病最常见的病因。肾纤维化程度与当前筛查指标之间的相关性较差。需要一种非侵入性成像技术来评估肾脏结构变化的程度。本研究的目的是评估表观扩散系数（ADC）在糖尿病肾病诊断中的作用。从我校附属医院肾内科招募了40例患有慢性肾病的成年糖尿病患者以及20例年龄和性别匹配的成年健康对照者。所有患者均使用相控阵体线圈在1.5-T扫描仪（飞利浦Achieva）上进行肾脏磁共振扩散加权成像（MR-DWI）和ADC图绘制。
在研究的40例糖尿病患者中，分为五组，每组8例，ADC值与肾实质病变进展呈负相关，即疾病晚期的ADC值低于早期。糖尿病肾病患者肾实质的平均ADC值明显低于肾功能正常的健康对照者（2.1±0.3×10⁻³mm²/s对2.4±0.1×10⁻³mm²/s，P<0.001）。
ADC值是一种可能的非侵入性技术，可用于评估肾功能不全的阶段并评估疾病进展。
