Esper Asil, Alhoulaiby Sami, Emran Areege, Youssef Safwan, Alshehabi Zuheir
Neurology Department, Tishreen University Hospital, Halap street, Latakia, Syria.
Faculty of Medicine, Damascus University, Damascus, Syria.
Oxf Med Case Reports. 2021 Jan 12;2021(1):omaa121. doi: 10.1093/omcr/omaa121. eCollection 2021 Jan.
Gorham-Stout disease (GSD) is a rare entity that destroys the bone matrix resulting mainly in osteolysis, pain and pathologic fractures among a broader clinical picture. We report a case of a 60-year-old female with a sudden discovery of pathologic fractures in the pelvis and the absence of the left femoral head. On biopsy, no cellular atypia was found, instead disturbed bone formation with prominent vascularity with scattered foci of necrosis & osteolysis, which lead to the diagnosis of GSD. Possible differential diagnoses were discussed and excluded. The patient was put on Bisphosphonate that led to a relative improvement in the symptoms. This disease needs a more thorough investigation to identify the key cause, what is beyond the scope of this report.
戈勒姆-斯托特病（GSD）是一种罕见的疾病，它破坏骨基质，在更广泛的临床症状中主要导致骨质溶解、疼痛和病理性骨折。我们报告一例60岁女性病例，该患者突然发现骨盆病理性骨折且左股骨头缺失。活检时未发现细胞异型性，而是骨形成紊乱，血管明显，伴有散在的坏死灶和骨质溶解，这导致了戈勒姆-斯托特病的诊断。讨论并排除了可能的鉴别诊断。患者接受了双膦酸盐治疗，症状有相对改善。这种疾病需要更深入的研究以确定关键病因，这超出了本报告的范围。
