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[急性心肌梗死成功溶栓治疗后的再闭塞]

[Reocclusion following successful thrombolytic therapy in acute myocardial infarct].

作者信息

Uebis R, Dörr R, Reynen K, Effert S

机构信息

Abteilung Innere Medizin I der Medizinischen Fakultät der RWTH Aachen.

出版信息

Klin Wochenschr. 1988;66 Suppl 12:115-8.

PMID:3347007
Abstract

Following successful reperfusion of the previously occluded coronary artery in acute myocardial infarction, reocclusion remains an at least partially unsolved problem. The literature reports figures between 10 and 30%. In the present study, 130 out of 543 patients with successful thrombolysis by means of intracoronary streptokinase underwent a follow-up angiography at the 3rd day (106/130, 80%) and/or 6 months (76/130, 59%) after the acute intervention. During the observation period, neither PTCA nor bypass surgery were performed. Reocclusion could be documented in 5.5% of patients at the early stage, and in 25.0% half a year later. In more than 75% of patients, who presented with a reoccluded infarct related artery, clinical evidence of reinfarction had been recorded during the follow-up period.

摘要

在急性心肌梗死中,先前闭塞的冠状动脉成功再灌注后,再闭塞仍然是一个至少部分未解决的问题。文献报道的发生率在10%至30%之间。在本研究中,543例通过冠状动脉内链激酶成功溶栓的患者中,130例在急性干预后第3天(106/130,80%)和/或6个月(76/130,59%)接受了随访血管造影。在观察期内,未进行经皮冠状动脉腔内血管成形术(PTCA)或搭桥手术。早期有5.5%的患者记录到再闭塞,半年后为25.0%。在超过75%的梗死相关动脉再闭塞的患者中,随访期间记录到了再梗死的临床证据。

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