Department of Pharmacy Practice & Pharmaceutical Sciences, University of Minnesota, College of Pharmacy, Duluth, MN 55812, USA.
Essentia Health, Duluth, MN 55805, USA.
Pharmacogenomics. 2021 Mar;22(4):203-212. doi: 10.2217/pgs-2020-0178. Epub 2021 Jan 20.
Pharmacogenetic (PGx) implementation has lagged behind the development of drug/gene pair guidelines. This was a prospective study assessing the integration of PGx through medication therapy management in an outpatient clinic. Variables collected included patient diagnosis, current medications, failed or discontinued medications, PGx results/recommendations, turnaround time and pre/post clinical ratings. A total of 91 participants completed study procedures with an average enrollment of approximately one consult per week. Participants were referred for testing primarily for guidance for current and future medications. The average number of recommendations per participant was 0.93. Integrating PGx testing into medication therapy management is feasible with PGx results available in under a week resulting in clinical recommendations in over half of patients tested.
药物遗传学（PGx）的实施落后于药物/基因对指导方针的发展。这是一项前瞻性研究，评估了通过门诊药物治疗管理来整合 PGx。收集的变量包括患者诊断、当前用药、失败或停用药物、PGx 结果/建议、周转时间和临床前后评估。共有 91 名参与者完成了研究程序，平均每周约有一次咨询。参与者进行测试主要是为了获得当前和未来药物治疗的指导。每位参与者的建议平均为 0.93 条。将 PGx 测试整合到药物治疗管理中是可行的，PGx 结果可在一周内获得，超过一半的测试患者可获得临床建议。
