Obstetrics and Gynecology Department, St Joseph University, Beirut, Lebanon.
Bellevue Medical Center Hospital, Hotel-Dieu de France Hospital, Beirut, Lebanon.
J Perinat Med. 2020 Dec 21;49(4):496-499. doi: 10.1515/jpm-2020-0457. Print 2021 May 26.
To report the normal fetal cardiac axis (CA) values at the time of the first trimester screening ultrasound.
Standardized images and measurement of the CA were obtained from 100 healthy fetuses between 11+0 and 13+6 weeks of gestation along with the nucal thichkness (NT), Crown-rump length (CRL) and other measurements. We excluded cases with abnormal NT, later diagnosis of abnormalities, and suspected fetal cardiopathy during the pregnancy follow-up. Data analysis was performed after all the patients delivered and cardiopathy was excluded.
CA was measurable in all the cases. Higher CRL was associated with a decrease in the CA. The mean ± SD embryonic/fetal CA was 48±5,2°, ranging from 39 to 60°, The 2.5 percentile was defined at 40° and the 97.5 percentile at 59°. The Pearson test resulted in a significant correlation between CA and CRL with a coefficient R of 70% and p-value <0.01.
CA tends to decrease at the 11 to 13+6 gestational ages. We defined 2.5 and 97.5% curves for the normal values of CA in our Middle Eastern population. A larger study will be required to differentiate normal and abnormal values for the early detection of heart abnormalities.
报告早孕期筛查超声时正常胎儿心脏轴（CA）值。
对 100 例 11+0 至 13+6 孕周的健康胎儿进行标准图像采集和 CA 测量，同时测量颈项透明层（NT）、头臀长（CRL）和其他测量值。我们排除了 NT 异常、妊娠期间诊断异常、胎儿心脏病可疑的病例。所有患者分娩后排除心脏病后进行数据分析。
所有病例均能测量 CA。CRL 越高，CA 越小。平均（±SD）胚胎/胎儿 CA 为 48±5.2°，范围为 39°至 60°。2.5 百分位定义为 40°，97.5 百分位定义为 59°。Pearson 检验表明 CA 与 CRL 之间存在显著相关性，相关系数 R 为 70%，p 值<0.01。
CA 在 11 周至 13+6 孕周时趋于下降。我们在中东人群中定义了 CA 的 2.5%和 97.5%曲线作为正常范围。需要更大的研究来区分正常和异常值，以早期发现心脏异常。
