Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
Department of Radiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
Turk J Med Sci. 2021 Feb 26;51(1):90-94. doi: 10.3906/sag-2001-48.
BACKGROUND/AIM: The aim of this study was to determine fetal nuchal translucency (NT) thickness nomogram values in first trimester in a Turkish population and compare them with previously reported European and Asian nomogram data.
Ultrasonographic measurements of crown-rump length (CRL) and NT thicknesses were obtained from 11 to 14 weeks of gestation in a normal Turkish population. Pregnant women with singleton pregnancy and fetal CRL between 45 and 84 mm were included in the study. The mean 1st, 3rd, 5th, 50th, 90th, 95th, 97th, and 99th percentiles and fixed cut off values of ≥ 2.5 mm, ≥ 3 mm, ≥ 3.5 mm NT thicknesses for a CRL between 45 and 84 mm were determined.
A total of 1605 healthy fetuses were enrolled in the study. The sonographic measurements were performed on 1541 (%94) fetuses transabdominally and on 99 cases (%4) by the transvaginal route. The mean NT thickness for CRL between 45 and 84 mm was 1.57 ± 074 mm, and the mean 95th, 97th, and 99th percentiles of these values were 2.82 mm, 3.17, and 4.75 mm, respectively. The incidence of NT thicknesses at fixed points of ≥ 2.5 mm, ≥ 3 mm, and ≥ 3.5 mm in normal fetuses were 6.7%, 4.1%, and 2.1%, respectively.
The present study demonstrated the nomogram data of fetal NT thickness in a Turkish population. We think that this report will be useful for further research related to NT thickness values on the prenatal diagnosis for the first trimester chromosomal abnormalities in Turkish populations.
背景/目的：本研究旨在确定土耳其人群中胎儿颈项透明层（NT）厚度的孕早期正常值，并与先前报道的欧洲和亚洲正常值数据进行比较。
在土耳其正常人群中，对 11-14 孕周的胎儿进行头臀长（CRL）和 NT 厚度的超声测量。纳入研究的孕妇为单胎妊娠且胎儿 CRL 在 45-84mm 之间。确定 45-84mm CRL 时 NT 厚度≥2.5mm、≥3mm、≥3.5mm 的第 1、3、5、50、90、95、97 和 99 百分位数和固定截断值。
本研究共纳入 1605 例健康胎儿。超声测量在 1541 例（94%）胎儿中经腹进行，在 99 例（4%）胎儿中经阴道进行。45-84mm CRL 时 NT 厚度的平均值为 1.57±0.74mm，这些值的第 95、97 和 99 百分位数分别为 2.82mm、3.17mm 和 4.75mm。在正常胎儿中，NT 厚度固定点≥2.5mm、≥3mm 和≥3.5mm 的发生率分别为 6.7%、4.1%和 2.1%。
本研究显示了土耳其人群中胎儿 NT 厚度的正常值数据。我们认为，本报告将有助于进一步研究土耳其人群中与 NT 厚度值相关的孕早期染色体异常的产前诊断。
