Department of Obstetrics and Gynecology, Donostia University Hospital, San Sebastian, Spain, Paseo Dr. Beguiristain, 107-115, 20014, San Sebastián, Gipúzkoa, Spain.
Department of Medical-Surgical Specialties, University of the Basque Country, Leioa, Spain.
Int Urogynecol J. 2021 Nov;32(11):3061-3067. doi: 10.1007/s00192-020-04661-2. Epub 2021 Jan 20.
This study was aimed at investigating risk factors involved in stress urinary incontinence (SUI) 12 years after first delivery. We also evaluated cumulative incidence, severity, and impact on quality of life (QoL) of SUI. We hypothesized that changes during the first pregnancy might be associated with SUI long after delivery.
A longitudinal cohort study was undertaken including primigravid women who delivered in our hospital during 2007. SUI was assessed following definitions of the International Continence Society. Severity was evaluated using the Incontinence Severity Index and impact on QoL with the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form. Comparisons between continuous variables were performed using Student's t test and between qualitative variables using Chi-squared tests. A logistic regression model was constructed including variables that reached statistical significance (p < 0.05) in the univariate analysis.
During the inclusion period, 479 pregnant women were interviewed, 381 attended the 6-month follow-up, and 318 completed the questionnaires 12 years after and formed the study group. The cumulative incidence of SUI at 6 months and 12 years postpartum was 14.2% and 39.6% respectively. Generally, SUI severity was slight (73.0%) or moderate (28.9%) and its impact on QoL was low. Pregnancy SUI (OR: 2.14; 95% CI: 1.29-3.55) was independently associated with SUI 12 years postpartum.
The cumulative incidence of SUI increases markedly from 6 months to 12 years postpartum, being slight or moderate in severity and having a low impact on QoL in most cases. Developing SUI during pregnancy doubled the risk of SUI 12 years postpartum.
本研究旨在调查首次分娩后 12 年压力性尿失禁(SUI)相关的危险因素。我们还评估了 SUI 的累积发病率、严重程度和对生活质量(QoL)的影响。我们假设,首次妊娠期间的变化可能与分娩后很长时间的 SUI 有关。
本研究为纵向队列研究,纳入了 2007 年在我院分娩的初产妇。根据国际尿控协会的定义评估 SUI。使用尿失禁严重程度指数(Incontinence Severity Index)评估严重程度,使用国际尿失禁咨询问卷 - 尿失禁简短问卷(International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form)评估对 QoL 的影响。连续变量间的比较采用 Student's t 检验,定性变量间的比较采用卡方检验。对单变量分析中具有统计学意义的变量(p < 0.05)构建逻辑回归模型。
在纳入期间,共访谈了 479 名孕妇,其中 381 名在 6 个月时进行了随访,318 名在产后 12 年完成了问卷调查并构成了研究组。产后 6 个月和 12 个月的 SUI 累积发病率分别为 14.2%和 39.6%。通常,SUI 严重程度为轻度(73.0%)或中度(28.9%),对 QoL 的影响较低。妊娠时发生 SUI(OR:2.14;95% CI:1.29-3.55)与产后 12 年发生 SUI 独立相关。
产后 6 个月至 12 个月 SUI 的累积发病率显著增加,严重程度多为轻度或中度,在大多数情况下对 QoL 的影响较低。妊娠时发生 SUI 使产后 12 年发生 SUI 的风险增加了一倍。