Rortveit G, Hannestad Y S, Daltveit A K, Hunskaar S
Section for General Practice, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway.
Obstet Gynecol. 2001 Dec;98(6):1004-10. doi: 10.1016/s0029-7844(01)01566-6.
To investigate the association between parity and urinary incontinence, including subtypes and severity of incontinence, in an unselected sample, with special emphasis on age as a confounder or effect modifier.
This was a cross-sectional study (response rate 80%) with 27,900 participating women. Data on parity and urinary leakage, type, frequency, amount, and impact of incontinence were recorded by means of a questionnaire. A validated severity index was used. Relative risks (RR) with nulliparous women as reference were used as an effect measure.
Incontinence was reported by 25% of participants. Prevalences among nulliparous women ranged from 8% to 32%, increasing with age. Parity was associated with incontinence, and the first delivery was the most significant. The association was strongest in the age group 20-34 years with RR 2.2 (95% confidence interval [CI] 1.8, 2.6) for primiparous women and 3.3 (2.4, 4.4) for grand multiparous women. A weaker association was found in the age group 35-64 years (RRs between 1.4 and 2.0), whereas no association was found among women over 65 years. For stress incontinence in the age group 20-34 years, the RR was 2.7 (2.0, 3.5) for primiparous women and 4.0 (2.5, 6.4) for grand multiparous women. There was an association with parity also for mixed incontinence, but not for urge incontinence. Severity was not clinically significantly associated with parity.
Parity is an important risk factor for female urinary incontinence in fertile and peri- and early postmenopausal ages. Only stress and mixed types of incontinence are associated with parity. All effects of parity seem to disappear in older age.
在一个未经过筛选的样本中,研究生育胎次与尿失禁(包括尿失禁的亚型和严重程度)之间的关联,特别强调年龄作为一个混杂因素或效应修饰因素。
这是一项横断面研究(应答率80%),有27900名参与研究的女性。通过问卷调查记录生育胎次以及尿失禁情况、类型、频率、尿量和失禁的影响。使用经过验证的严重程度指数。以未生育女性作为参照,采用相对风险(RR)作为效应量度。
25%的参与者报告有尿失禁。未生育女性的患病率在8%至32%之间,随年龄增加而上升。生育胎次与尿失禁有关联,首次分娩的影响最为显著。在20 - 34岁年龄组中,这种关联最为强烈,初产妇的RR为2.2(95%置信区间[CI] 1.8, 2.6),多产妇的RR为3.3(2.4, 4.4)。在35 - 64岁年龄组中发现的关联较弱(RR在1.4至2.0之间),而在65岁以上女性中未发现关联。对于20 - 34岁年龄组的压力性尿失禁,初产妇的RR为2.7(2.0, 3.5),多产妇的RR为4.0(2.5, 6.4)。混合性尿失禁也与生育胎次有关联,但急迫性尿失禁与生育胎次无关。严重程度与生育胎次在临床上无显著关联。
生育胎次是育龄期、围绝经期和绝经后早期女性尿失禁的一个重要危险因素。只有压力性和混合性尿失禁类型与生育胎次有关联。生育胎次的所有影响在老年时似乎都会消失。