Deputy Director of Research, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Endocrinological and Nutritional Epidemiology Research Unit, Universidad Nacional Autónoma de México and Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
Endocr Pract. 2020 Oct;26(10):1053-1061. doi: 10.4158/EP-2020-0047.
The most commonly used methods for bone age (BA) reading were described in the Caucasian population decades ago. However, there are secular trends in skeletal maturation and different BA patterns between ethnic groups. Automated BA reading makes updating references easier and more precise than human reading. The objective of the present study was to present automated BA reference curves according to chronological age and gender in the Mexican population and compare the maturation tempo with that of other populations.
The study included 923 healthy participants aged 5 to 18 years between 2017 and 2018. A hand radio-graph was analyzed using BoneXpert software to obtain the automated BA reading according to Greulich and Pyle (G&P) and Tanner-Whitehouse 2 (TW2) references. We constructed reference curves using the average difference between the BA and chronological age according to sex and age.
The G&P and TW2 automated reference curves showed that Mexican boys exhibit delays in BA during middle childhood by 0.5 to 0.7 (95% confidence interval [CI], -0.9 to -0.2) years; however, they demonstrate an advanced BA of up to 1.1 (95% CI, 0.8 to 1.4) years at the end of puberty. Mexican girls exhibited a delay in BA by 0.3 to 0.6 (95% CI, -0.9 to -0.1) years before puberty and an advanced BA of up to 0.9 (95% CI, 0.7 to 1.2) years at the end of puberty.
Mexican children aged <10 years exhibited a delay in skeletal maturity, followed by an advanced BA by approximately 1 year at the end of puberty. This may affect the estimation of growth potential in this population.
几十年前，描述了白种人群体中最常用的骨龄（BA）阅读方法。然而，骨骼成熟和不同种族之间的 BA 模式存在季节性趋势。自动 BA 阅读使更新参考资料变得更加容易和精确，而不是人工阅读。本研究的目的是呈现墨西哥人群中按年龄和性别划分的自动 BA 参考曲线，并比较与其他人群的成熟速度。
本研究纳入了 2017 年至 2018 年间 923 名年龄在 5 至 18 岁的健康参与者。使用 BoneXpert 软件对手部 X 光片进行分析，根据 Greulich 和 Pyle（G&P）和 Tanner-Whitehouse 2（TW2）参考标准获得自动 BA 阅读。我们根据性别和年龄构建了 BA 与年龄平均差值的参考曲线。
G&P 和 TW2 自动参考曲线显示，墨西哥男孩在童年中期 BA 延迟 0.5 至 0.7 岁（95%置信区间 [CI]，-0.9 至-0.2）；然而，他们在青春期结束时 BA 提前高达 1.1 岁（95% CI，0.8 至 1.4）。墨西哥女孩在青春期前 BA 延迟 0.3 至 0.6 岁（95% CI，-0.9 至-0.1），在青春期结束时 BA 提前高达 0.9 岁（95% CI，0.7 至 1.2）。
10 岁以下的墨西哥儿童骨骼成熟度延迟，随后在青春期结束时 BA 提前约 1 年。这可能会影响对该人群生长潜力的估计。
