School of Computer Science and Technology, Henan Polytechnic University, Jiaozuo, Henan, China.
PLoS One. 2021 Jan 20;16(1):e0245506. doi: 10.1371/journal.pone.0245506. eCollection 2021.
In order to solve the problems of low computational security in the encoding mapping and difficulty in practical operation of biological experiments in DNA-based one-time-pad cryptography, we proposed a one-time-pad cipher algorithm based on confusion mapping and DNA storage technology. In our constructed algorithm, the confusion mapping methods such as chaos map, encoding mapping, confusion encoding table and simulating biological operation process are used to increase the key space. Among them, the encoding mapping and the confusion encoding table provide the realization conditions for the transition of data and biological information. By selecting security parameters and confounding parameters, the algorithm realizes a more random dynamic encryption and decryption process than similar algorithms. In addition, the use of DNA storage technologies including DNA synthesis and high-throughput sequencing ensures a viable biological encryption process. Theoretical analysis and simulation experiments show that the algorithm provides both mathematical and biological security, which not only has the difficult advantage of cracking DNA biological experiments, but also provides relatively high computational security.
为了解决基于 DNA 的一次性密码本加密算法中编码映射的计算安全性低和生物实验实际操作困难的问题，我们提出了一种基于混淆映射和 DNA 存储技术的一次性密码本加密算法。在我们构建的算法中，使用混沌映射、编码映射、混淆编码表和模拟生物操作过程等混淆映射方法来增加密钥空间。其中，编码映射和混淆编码表为数据和生物信息的转换提供了实现条件。通过选择安全参数和混淆参数，该算法实现了比类似算法更随机的动态加密和解密过程。此外，使用包括 DNA 合成和高通量测序在内的 DNA 存储技术确保了可行的生物加密过程。理论分析和仿真实验表明，该算法提供了数学和生物安全性，不仅具有破解 DNA 生物实验的困难优势，而且还提供了相对较高的计算安全性。
