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抗体药物偶联物治疗恶性肿瘤临床应用专家共识(2020年版)

[Expert consensus on the clinical application of antibody drug conjugates in the treatment of malignant tumors (2020 Edition)].

出版信息

Zhonghua Zhong Liu Za Zhi. 2021 Jan 23;43(1):78-91. doi: 10.3760/cma.j.cn112152-20201112-00981.

Abstract

Antibody-drug conjugate (ADC) is a type of targeted biological agent which connect cytotoxic drug to monoclonal antibody by a connector head, which enables monoclonal antibody acted as a carrier to efficiently transport small molecular cytotoxic drugs to target tumor cells. It is very important for clinicians to have an in-depth understanding of the molecular characteristics and mechanism of ADC drugs, rationally choose the appropriate dose, course of treatment and manage adverse reactions according to the indications during the clinical application of ADC drugs, which may even affect the survival of patients. Therefore, the consensus aims to conduct a systematic overview of commercially available ADC drugs, provide effective recommendations and references for clinicians to better apply and manage ADC drugs.

摘要

抗体药物偶联物(ADC)是一种靶向生物制剂,它通过连接子将细胞毒性药物与单克隆抗体连接起来,使单克隆抗体作为载体,能够有效地将小分子细胞毒性药物转运至靶肿瘤细胞。临床医生深入了解ADC药物的分子特征和作用机制,在ADC药物临床应用过程中根据适应证合理选择合适的剂量、疗程并处理不良反应,这对临床医生而言非常重要,甚至可能影响患者的生存。因此,本共识旨在对市售ADC药物进行系统综述,为临床医生更好地应用和管理ADC药物提供有效的建议和参考。

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