Li Q, Li Y Q, Zhang H G, Yihebali Chi, Wang X Y, Yang L, Zhou A P, Song Y, Sun Y K, Wang J W, Wu L Y, Huang J
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhonghua Zhong Liu Za Zhi. 2021 Jan 23;43(1):132-136. doi: 10.3760/cma.j.cn112152-20200601-00504.
To explore the clinicopathological characteristics and prognosis of patients with ovarian metastases from colorectal cancer. A total of 122 female patients with ovarian metastases from colorectal cancer underwent treatment in Cancer Hospital, Chinese Academy of Medical Sciences between 2010 and 2015 were recruited. The clinicopathological features, treatment details and survival data of these patients were retrospectively analyzed. Kaplan-Maier method was used for survival analysis, log rank test and Cox proportional hazards model were used for prognostic factor analysis. The median overall survival (OS) was 19.7 months. The 1-year, 3-years and 5-years OS rates were 72.1%, 24.7% and 9.9%, respectively. A total of 99 (81.1%) patients underwent oophorectomy. The median OS of patients who underwent oophorectomy was 21.9 months, significantly longer than 10.3 months of patients without oophorectomy (<0.01). Ovary as the only site of metastasis, primary tumor resection, and oophorectomy were associated with improved survival (all <0.01). Primary tumor resection and oophorectomy were independent prognostic factors for OS (both <0.01). Patients with ovarian metastases from colorectal cancer might acquire a survival benefit from surgical resection of the primary tumor and ovaries.
探讨结直肠癌卵巢转移患者的临床病理特征及预后。选取2010年至2015年间在中国医学科学院肿瘤医院接受治疗的122例结直肠癌卵巢转移女性患者。对这些患者的临床病理特征、治疗细节及生存数据进行回顾性分析。采用Kaplan - Maier法进行生存分析，对数秩检验和Cox比例风险模型进行预后因素分析。中位总生存期（OS）为19.7个月。1年、3年和5年OS率分别为72.1%、24.7%和9.9%。共有99例（81.1%）患者接受了卵巢切除术。接受卵巢切除术患者的中位OS为21.9个月，显著长于未接受卵巢切除术患者的10.3个月（<0.01）。卵巢为唯一转移部位、原发肿瘤切除及卵巢切除术与生存改善相关（均<0.01）。原发肿瘤切除及卵巢切除术是OS的独立预后因素（均<0.01）。结直肠癌卵巢转移患者可能从原发肿瘤和卵巢的手术切除中获得生存益处。
