Choi Sangjoon, Cho Junhun, Lee Seung Eun, Baek Chung-Hwan, Kim Yi-Kyung, Kim Hyung-Jin, Ko Young Hyeh
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Pathology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
J Pathol Transl Med. 2021 Mar;55(2):132-138. doi: 10.4132/jptm.2020.12.11. Epub 2021 Jan 22.
Salivary gland tumors are histologically diverse, and each entity has distinctive histopathological and molecular features. We report two cases of salivary gland tumors with unique histological and molecular findings, which have not been documented previously. The tumors were located in the base of the tongue in both patients. Most tumor cells were arranged in cords and nests, giving a trabecularlike appearance. Focally, glandular structures with intraluminal mucin and perivascular pseudorosette-like configurations were identified. Tumor cells had eosinophilic to clear cytoplasm, and showed mild nuclear atypia. They were positive for pancytokeratin and negative for S-100, p63, c-KIT, androgen receptor, and neuroendocrine markers. Multiple foci of capsular or lymphovascular invasion were identified, but the Ki-67 labeling index was low (< 5%). Fluorescence in situ hybridization revealed concurrent alterations of MAML2 and EWSR1 gene. Further investigations with a larger number of cases with similar histological and molecular features will accurately classify this tumor.
唾液腺肿瘤在组织学上具有多样性，每个实体都有独特的组织病理学和分子特征。我们报告了两例具有独特组织学和分子学发现的唾液腺肿瘤，此前尚未见相关文献记载。两名患者的肿瘤均位于舌根。大多数肿瘤细胞呈条索状和巢状排列，呈小梁样外观。局部可见含有腔内黏液和血管周围假菊形团样结构的腺管结构。肿瘤细胞胞质嗜酸性至透明，核轻度异型。它们全细胞角蛋白呈阳性，而S-100、p63、c-KIT、雄激素受体和神经内分泌标志物呈阴性。发现多个包膜或脉管侵犯灶，但Ki-67标记指数较低（<5%）。荧光原位杂交显示MAML2和EWSR1基因同时发生改变。对更多具有相似组织学和分子特征病例的进一步研究将准确地对该肿瘤进行分类。
