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A Novel Point Mutation in the N Gene of SARS-CoV-2 May Affect the Detection of the Virus by Reverse Transcription-Quantitative PCR.

作者信息

Hasan Mohammad Rubayet, Sundararaju Sathyavathi, Manickam Chidambaram, Mirza Faheem, Al-Hail Hamad, Lorenz Stephan, Tang Patrick

机构信息

Sidra Medicine, Doha, Qatar

Weill Cornell Medicine-Qatar, Doha, Qatar.

出版信息

J Clin Microbiol. 2021 Mar 19;59(4). doi: 10.1128/JCM.03278-20.

DOI:10.1128/JCM.03278-20

PMID:33472904

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8092750/

Abstract

摘要

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本文引用的文献

Identification of a Polymorphism in the N Gene of SARS-CoV-2 That Adversely Impacts Detection by Reverse Transcription-PCR.

J Clin Microbiol. 2020 Dec 17;59(1). doi: 10.1128/JCM.02369-20.

SARS-CoV-2 samples may escape detection because of a single point mutation in the N gene.

Euro Surveill. 2020 Oct;25(39). doi: 10.2807/1560-7917.ES.2020.25.39.2001650.

Mutations on COVID-19 diagnostic targets.

Genomics. 2020 Nov;112(6):5204-5213. doi: 10.1016/j.ygeno.2020.09.028. Epub 2020 Sep 20.

A Recurrent Mutation at Position 26340 of SARS-CoV-2 Is Associated with Failure of the E Gene Quantitative Reverse Transcription-PCR Utilized in a Commercial Dual-Target Diagnostic Assay.

J Clin Microbiol. 2020 Sep 22;58(10). doi: 10.1128/JCM.01598-20.

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.

Euro Surveill. 2020 Jan;25(3). doi: 10.2807/1560-7917.ES.2020.25.3.2000045.

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A Novel Point Mutation in the N Gene of SARS-CoV-2 May Affect the Detection of the Virus by Reverse Transcription-Quantitative PCR.

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