Divisions of Pediatric Pulmonary and Sleep Medicine,
Pediatrics, Seattle Children's Hospital and University of Washington, Seattle, Washington.
Pediatrics. 2021 Apr;147(4). doi: 10.1542/peds.2020-033092. Epub 2021 Jan 20.
We describe the presentation and diagnosis of a child with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis and associated diffuse alveolar hemorrhage who was positive for coronavirus disease 2019 immunoglobulin G antibodies, indicative of a previous asymptomatic infection. Results of multiple polymerase chain reaction tests coinciding with the start of symptoms were negative, indicating that acute infection was not the cause of the patient's symptoms. Coronavirus disease 2019-induced autoimmune diseases have been described in adults, but this case report represents the first case described in a pediatric patient.
我们描述了一例新诊断的抗中性粒细胞胞质抗体相关性血管炎和弥漫性肺泡出血患儿的表现和诊断，该患儿新冠病毒 IgG 抗体阳性，提示曾有无症状感染。与症状开始时相符的多次聚合酶链反应检测结果均为阴性，表明急性感染不是该患儿症状的原因。成人中已描述了新冠病毒导致的自身免疫性疾病，但本病例报告代表了首例儿科患者的病例描述。
