Department of Medical Oncology, Hacettepe University, Ankara, Turkey.
Department of Hematology, Hacettepe University, Ankara, Turkey.
Niger J Clin Pract. 2021 Jan;24(1):17-20. doi: 10.4103/njcp.njcp_84_20.
Thrombocytopenia is defined as the platelet count of less than 150 × 109/L and is a prominent cause of bleeding. Aplastic anemia (AA), immune thrombocytopenic purpura (ITP), and thrombotic thrombocytopenic purpura (TTP) are some of the reasons of low platelet counts.
We aimed to interpret different laboratory and clinical findings in these different reasons of thrombocytopenia.
Among patients with these disorders we assessed the performance of the ITP Bleeding Scale Assessment (ITP-BSA), which is principally designed for ITP patients.
A hundred patients were included in analysis. Median platelet count at presentation was similar in all three groups. Thrombosis was seen more common in patients with TTP (20.7%) than the others (ITP; 5.6%, AA; 2.9%). In patients with TTP, sepsis (41.4%) and neurological findings (89.7%) are also more common than in the patients with ITP or AA. Bleeding was determined in all patients with AA. However, 13 patients with ITP (%36.1) and 10 patients with TTP (%34.5) had no bleeding. The most common bleeding site was skin in all three groups. There was not any gastrointestinal, lung, genitourinary, and cranial bleeding in patients with ITP. Patients with AA obtained the highest scores from the ITP-BSA. There was a significant difference between AA and the other two groups. The scores were found similar in patients with ITP and TTP (P = 0.17).
Clinical variations in thrombocytopenic patients may vary and assist to diagnose the cause of thrombocytopenia. The bleeding scoring systems might be helpful.
血小板减少症定义为血小板计数低于 150×109/L，是出血的主要原因。再生障碍性贫血（AA）、免疫性血小板减少性紫癜（ITP）和血栓性血小板减少性紫癜（TTP）是血小板计数降低的一些原因。
我们旨在解释血小板减少症的这些不同原因中的不同实验室和临床发现。
在患有这些疾病的患者中，我们评估了主要为 ITP 患者设计的 ITP 出血量表评估（ITP-BSA）的表现。
共有 100 名患者纳入分析。所有三组患者的血小板计数在就诊时相似。血栓形成在 TTP 患者中更为常见（20.7%），而在其他患者中则较少（ITP：5.6%，AA：2.9%）。在 TTP 患者中，败血症（41.4%）和神经学发现（89.7%）也比 ITP 或 AA 患者更为常见。AA 患者均有出血。然而，13 名 ITP 患者（36.1%）和 10 名 TTP 患者（34.5%）没有出血。所有三组患者最常见的出血部位均为皮肤。在 ITP 患者中没有胃肠道、肺部、泌尿生殖系统和颅出血。AA 患者的 ITP-BSA 评分最高。AA 与其他两组之间存在显著差异。ITP 和 TTP 患者的评分相似（P=0.17）。
血小板减少症患者的临床差异可能不同，并有助于诊断血小板减少症的原因。出血评分系统可能会有所帮助。
