Comparative study between two bleeding grading systems of immune thrombocytopenia purpura.

OBJECTIVE

To explore the relationship between platelet count and bleeding score in immune thrombocytopenia purpura (ITP) and compare the clinical practicability of two bleeding grading systems with adult patients with ITP.

METHODS

A total of 204 patients were retrospectively analyzed with the ITP bleeding scale (IBLS) and the ITP bleeding assessment tool (version 2016) (ITP-2016). The correlation between the two bleeding score systems and the relations among the platelet counts were respectively analyzed.

RESULTS

(1) There is a linear relationship between platelet count and bleeding score, no matter which scoring system it is based on (rs = -0.429,  < 0.001; rs = -0.331,  < 0.001, the analysis of the number of sites of Grade 1/2 bleeding were done; and rs = -0.466,  < 0.05, the analysis between platelet count and bleeding score by ITP-2016 respectively). (2) Platelet count and bleeding scores are negatively correlated in those with extremely low platelet counts ( < 1010/L). The number of sites of Grade 2 bleeding and the ITP-2016 scores are negatively correlated with platelet counts (rs = -0.15 and rs = -0.244,  < 0.05, respectively). Significantly, there is no correlation between the platelet count and bleeding scores when the platelet count is more than 1010/L. (3) It takes less time to score with ITP-2016 than IBLS ( = -3.825,  < 0.001).

CONCLUSIONS

There is good responsiveness, strong assessment consistency, close correlation between ITP-2016 and IBLS. ITP-2016 takes less time-consuming in clinical application. It can be used as an effective tool of condition judgement, risk assessment and efficacy evaluation of patients with ITP.