GIGA-Neurosciences, Cell Biology Unit, University of Liège.
Department of Otolaryngology, Case Western Reserve University.
Cell Struct Funct. 2021 Mar 16;46(1):11-20. doi: 10.1247/csf.20057. Epub 2021 Feb 6.
The development of hearing in mammals requires the formation and maturation of a highly organized and specialized epithelium known as the organ of Corti. This epithelium contains two types of cells, the sensory cells, which are the true receptors of auditory information, and the surrounding supporting cells, which are composed of a highly developed cytoskeleton essential to the architecture of the mature organ of Corti. The supporting cells are the only mammalian cells reported to contain the unusual 15-protofilament microtubules. In this paper, we show that 15-protofilament microtubules appear between the second and fourth day after birth in the pillar cells of the organ of Corti in mice. We also show that contrary to what has been described in the nematode worm Caenorhabiditis. elegans, microtubule acetylation is not essential for the formation of 15-protofilament microtubules in mice but is required for fine-tuning of their diameter.Key words: Acetylation, cytoskeleton, microtubule, inner ear, supporting cells.
哺乳动物听力的发展需要形成和成熟高度组织化和专业化的上皮组织，称为柯蒂氏器。该上皮组织包含两种细胞，感觉细胞，是听觉信息的真正受体，以及周围的支持细胞，由成熟柯蒂氏器结构所必需的高度发达的细胞骨架组成。支持细胞是唯一被报道含有不寻常的 15 原纤维微管的哺乳动物细胞。在本文中，我们表明，15 原纤维微管在出生后第二天至第四天出现在小鼠柯蒂氏器的柱状细胞之间。我们还表明，与线虫秀丽隐杆线虫中描述的情况相反，微管乙酰化对于在小鼠中形成 15 原纤维微管不是必需的，但对于微调其直径是必需的。关键词：乙酰化，细胞骨架，微管，内耳，支持细胞。
